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A neuroimaging study of the neural circuitry implicated in reward processing in early psychostimulant use: Altered striatal activation in response to rewarding stimuli in methamphetamine dependent subjects.
The dopamine system in the striatum has been well characterized as a major structure implicated in reward processing, however, their role in responding to the rewarding effects of methamphetamine (METH) use has not been clearly identified. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neuroanatomical basis of reward processing. Using blood oxygen level-dependent (BOLD) fMRI, 32 adult methamphetamine abusers (MA) and 32 non-drug-using healthy controls (HC) were scanned after self-administration of METH or placebo. The BOLD response to pictures of one’s own-name was analyzed. Reward was defined as the contrast of own name versus fixation. We found MA to have lower ventral striatal activation in the left nucleus accumbens and posterior putamen than HC in response to the rewarding effects of METH. The findings suggest that in MA the reward function is reduced in ventral striatal structures. It is our hope that further investigation of this reward deficit may shed light on the etiology of addiction and relapse.Parc Branchline
The Parc Branchline was a passenger railway line in Blaenau Gwent from Brynmawr to Parc.
History
Opening
The branchline opened in 1912, and the section from Llanharry to Brynmawr became a through station. The section to Parc had opened on 3 January 1901.
Traffic
The railway was mainly used by the hosiery company: Harland and Wolff which had a large factory at Parc, and hosiery factories at Brynmawr, Llanharry and Blaenau Ffestiniog.
Closure
The line closed for good on 9 December 1964, although the section to Blaenau Ffestiniog remained open until 1972.
Present day
The track remains intact for about half a mile from Brynmawr to Llanharry where it is used by narrow-gauge railways to haul clay from the quarry at Glyn Padarn to the Brynmawr Marshalling Yard.
References
External links
Category:Disused railway stations in
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