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Might and Magic Heroes 2, 3, 4, 5, 6, 7 are the latest game installments of the Might and Magic series. This page is available in multiple languages. Download the freeware or pay the full price.Long non-coding RNA BNCR1 promotes the proliferation, migration and invasion of breast cancer cells by inactivation of microRNA-138.
Breast cancer is one of the most common cancer in women. Recently, lncRNAs were revealed to play important roles in the growth, progression, metastasis and the drug resistance in many types of cancers. However, the role of long non-coding RNA breast cancer related 1 (BNCR1) in breast cancer remains unknown. In this study, we reported that BNCR1 was up-regulated in breast cancer and high expression of BNCR1 was a bad prognosis factor. Overexpression of BNCR1 promoted cell proliferation, colony formation, migration and invasion of breast cancer cells. In contrast, knockdown of BNCR1 inhibited cell proliferation, colony formation, migration and invasion of breast cancer cells. Moreover, BNCR1 promoted cell cycle progression and up-regulated expression of Cyclin D1, CDK2, CDK4 and Cyclin E1. The results showed that BNCR1 can function as a molecular sponge for miR-138, and miR-138 targeted Cyclin D1 and CDK4. Furthermore, miR-138 overexpression abrogated the cell proliferation, colony formation, migration and invasion of breast cancer cells promoted by BNCR1. Taken together, our data suggested that BNCR1 may be a oncogene in breast cancer and miR-138 overexpression may inhibit cell growth, colony formation, migration and invasion of breast cancer cells through targeting Cyclin D1 and CDK4.Q:
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