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The aim of this study was to determine the capacity of the intestine to extract bilirubin from the blood after an enterohepatic circulation. The model was based on the following assumptions. Bilirubin is actively transported along the intestine as a molecule in the portal blood and follows the secretory cycle of the acinar epithelial cells. In the duodenum at the catheter tip, the direction of the transport is toward the serosa, and along the basement membrane. Bilirubin passes the tight junctions and is transported to the portal plasma. There it is actively transported back along the intestine, where it is presumably secreted into the gut lumen. To this end a two-dimensional mathematical model was developed, which used the five cell layers of the mucosa and submucosa of the rat small intestine as a lumped parameter model to depict a distribution of the diffusive and the active transport processes across the epithelial cell wall. Cell growth was described according to a Gompertz-type growth function. Various rate equations were used to describe uptake and release of bilirubin, diffusion through the epithelial cells, as well as the cell renewal. The net transport of bilirubin along the small intestine was determined in a mathematical model using physiologic conditions. The results indicate that with an appropriate choice of the parameter values, it is possible to reproduce, in a qualitative manner, a variety of observed experimental results. In particular, the model describes a pattern of blood bilirubin concentrations in the intestine as measured after an enterohepatic circulation.Q:
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